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. 2017 Mar 10;8(15):25525–25541. doi: 10.18632/oncotarget.16066

Figure 5. Lunasin reduced pulmonary metastases in vivo.

Figure 5

B16-F10 melanoma cells were injected IV into female C57BL/6 mice. Lunasin-treated mice had less incidence of macrometastases (A) as well as significantly reduced average lesion area (B). Representative images of pulmonary tissues resected from control (C) and Lunasin (D) treated mice are shown. H&E stained sections demonstrate the significant difference between average lesion area in vehicle (E) and Lunasin (F) treated mice. Stained sections were imaged at 10x (left) and 40x (right), scale bar = 1 mm. Graphs represent data plotted as mean ± s.e.m. Means were determined to be statistical significant by student's t-test and significance is denoted by an asterisk.