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. 2017 Jan 29;8(15):25721–25735. doi: 10.18632/oncotarget.14891

Figure 2. Lin28′s let-7-dependent functionality.

Figure 2

A primary let-7 (pri-let-7) transcript produced by let-7 gene is processed by the Drosha DGCR8 microprocessor in the nucleus. Then the generated precursor let-7 (pre-let-7) is transported to the cytosol and further processed by the Dicer and Argonaute proteins (AGO) to generate the mature let-7. The biogenesis of pri-let-7 is blocked by Lin28A in the nucleus and Lin28B in the nucleolus, the biogenesis of pre-let-7 and mature let-7 are blocked by Lin28A/B in the cytosol, and the mature let-7 can in turn block the biogenesis of Lin28A/B. Solid line arrows refer to induction and promotion, dash line arrows refer to only promotion, while hammerheads refer to inhibition.