Table 2. Symptomatic response to palliative radiotherapy for gastric cancer.
| Author/ year |
Radiotherapy (dose/fraction size/treatment period |
Index symptom | Response | Survival (months) | Duration (months) | BED correlation |
|---|---|---|---|---|---|---|
| Kim MM 20086 |
Median 35Gy (25-36Gy), 24/37 patients had concurrent chemotherapy) |
Gastric bleeding, pain, obstruction | Bleeding 70%(14/20), pain 86% (6/7), obstruction 81% (13/16) | 5.2 | Bleeding (11.4), pain (NR), obstruction (6.2) | BED 41 Gy10 conferred better local control of symptoms but not overall survival |
| Hashimoto 200912 |
Median 40Gy (2-50Gy in 1.8-3Gy / fr) (4/19 patients had CRT) |
Gastric bleeding | Bleeding 68% (13/19) | 3.4 | 1.5 | BED 50 Gy10 conferred higher success rate of haemostasis compared to those received BED <50 Gy10 |
| Lee JA 200913 |
30 Gy / 10 fr (12/30 patients had CRT) |
Gastric bleeding | Bleeding 91% (21/23) | 4 | 4 | NR |
| Asakura 201114 |
30 Gy / 10 fr (12/30 patients had concurrent chemotherapy) |
Gastric bleeding | Bleeding 73% (22/30) | 3.6 | 3.3 | BED 39 Gy10, conferred a response rate comparable to higher BED (50 Gy10 or more) |
| Chaw 20145 |
8Gy single fr 20Gy / 5 fr |
Gastric bleeding | Bleeding 50% (22/44, 8 patients unevaluable) | 5.3 | NR | BED 28 Gy10, conferred a similar response rate compared to other studies |
| Tey 201415 |
8-40Gy | Bleeding, pain, obstruction | Bleeding 80.6%(83/103), pain 45.5% (5/11), obstruction 51.2% (9/17) | 2.8 | Bleeding (3.3), pain (7.8), obstruction (3.2) | Trend for poorer local control for BED ≤39 Gy10 |
| Kondoh 201516 | Median 30Gy (30-40Gy in 2-3Gy / fr) (5/15 patients had CRT) |
Bleeding | Bleeding 80.6%(11/15-RT:7/15 CRT: 4/15) |
2.1 | NR | NR |