Table 3. Significant findings of gray matter volume decreases in AD patients with few or multiple neuropsychiatric symptoms in comparison with healthy controls (with correction for multiple comparisons over the whole brain, p<0.05).
| Brain region (BA)a | Hemisphere | MNI coordinatesb x y z |
Kc | Z scored | p (FWE corr) e Peak-level |
|---|---|---|---|---|---|
| AD with few NPS (n = 7) versus controls (n = 13) | |||||
| Superior frontal gyrus (BA9) (extended to medial frontal gyrus) | Right | 13 55 34 | 443 | 5.10 | 0.009 |
| Anterior cingulate gyrus (BA32) (extended to medial frontal gyrus) | Left | -2 25 28 | 2173 | 4.92 | 0.019 |
| Postcentral gyrus (BA2) (extended to inferior parietal lobule) | Right | 37–30 44 | 437 | 4.85 | 0.024 |
| Postcentral gyrus (BA2) (extended to inferior parietal lobule and precentral gyrus) | Left | -38–28 46 | 807 | 4.69 | 0.044 |
| AD with multiple NPS (n = 12) versus controls (n = 13) | |||||
| Superior temporal gyrus (BA38) (extended to parahippocampal gyrus, middle temporal gyrus, and insula) | Left | -44 10–31 | 3709 | 4.71 | 0.032 |
a BA = Approximate Brodmann Area.
b Voxel coordinates of maximal statistical significance in the cluster.
c Total voxels number in each cluster with Z>3.09 (corresponding to P≤ 0.001) and k>25
d Z scores for the voxel of maximal statistical significance in each cluster.
e Statistical significance after correction for multiple comparisons at voxel level