Table 4. Additional findings of gray matter volume decreases in AD patients with few neuropsychiatric symptoms in comparison with healthy controls, corrected for multiple comparisons using the flexible, small-volume correction (SVC) method.
| Brain region (BA)a | Hemisphere | MNI coordinatesb x y z |
Kc | Z scored | p (FWE corr) e Peak-level |
|---|---|---|---|---|---|
| Parahippocampal gyrus—Uncus (BA38) | Right | 24 9–32 | 167 | 3.81 | 0.021 |
| Superior temporal gyrus (BA38) | Left | -43 10–31 | 545 | 4.26 | 0.004 |
| Right | 47 15–28 | 106 | 3.57 | 0.038 | |
| Middle temporal gyrus (BA21) | Left | -44 7–29 | 105 | 4.04 | 0.031 |
| Left | -66–19–9 | 248 | 4.00 | 0.035 |
a BA = Approximate Brodmann Area.
b Voxel coordinates of maximal statistical significance in the cluster.
c Total voxels number in each cluster with Z>3.09 (corresponding to P≤ 0.001) and k>25
d Z-score for the voxel of maximal statistical significance in each region.
e Statistical significance after correction for multiple comparisons at the voxel level