Table 5. Additional findings of gray matter volume decreases in AD patients with multiple neuropsychiatric symptoms in comparison with healthy controls, corrected for multiple comparisons using the flexible, small-volume correction (SVC) method.
| Brain region (BA)a | Hemisphere | MNI coordinatesb x y z |
Kc | Z scored | p (FWE corr)e Peak-level |
|---|---|---|---|---|---|
| Anterior cingulate gyrus (BA32) | Left | -8 35 24 | 500 | 4.22 | 0.004 |
| Medial frontal gyrus (BA9) | Right | 16 34 45 | 209 | 4.28 | 0.015 |
| Middle frontal gyrus (BA9) | Left | -33 27 39 | 154 | 4.36 | 0.009 |
| Left | -38 4 52 | 122 | 4.04 | 0.028 |
a BA = Approximate Brodmann Area.
b Voxel coordinates of maximal statistical significance in the cluster.
c Total voxels number in each cluster with Z>3.09 (corresponding to P≤ 0.001) and k>25
d Z-score for the voxel of maximal statistical significance in each region.
e Statistical significance after correction for multiple comparisons at the voxel level