Skip to main content
. 2017 May 8;12(5):e0177169. doi: 10.1371/journal.pone.0177169

Table 5. Additional findings of gray matter volume decreases in AD patients with multiple neuropsychiatric symptoms in comparison with healthy controls, corrected for multiple comparisons using the flexible, small-volume correction (SVC) method.

Brain region (BA)a Hemisphere MNI coordinatesb
x y z
Kc Z scored p (FWE corr)e
Peak-level
Anterior cingulate gyrus (BA32) Left -8 35 24 500 4.22 0.004
Medial frontal gyrus (BA9) Right 16 34 45 209 4.28 0.015
Middle frontal gyrus (BA9) Left -33 27 39 154 4.36 0.009
Left -38 4 52 122 4.04 0.028

a BA = Approximate Brodmann Area.

b Voxel coordinates of maximal statistical significance in the cluster.

c Total voxels number in each cluster with Z>3.09 (corresponding to P≤ 0.001) and k>25

d Z-score for the voxel of maximal statistical significance in each region.

e Statistical significance after correction for multiple comparisons at the voxel level