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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Autoimmun. 2017 Feb 7;80:39–47. doi: 10.1016/j.jaut.2017.01.006

Figure 6. PAD2 is required for TNFα-induced inflammatory arthritis.

Figure 6

A. Severity of clinical arthritis was scored on a scale of 0–3 in 2, 3, and 4 month old TNF+PAD2+/+ and TNF+PAD2−/− mice including (left) or not including (right) grip strength with average and SEM graphed (2 and 3 months: n=25 TNF+PAD2+/+ and n=24 TNF+PAD2−/− mice; 4 months: n=19 pairs; *p<0.05). The ankles of 4–5 month old TNF+PAD2+/+ and TNF+PAD2−/− mice were fixed, sectioned, and stained with H&E. B. Representative images with arrows indicating inflamed synovium/pannus invading the tibio-talar joint (Magnification 100x, bar 500 μm). The percentage of surface erosion (C) and extent of synovitis on a scale of 0–4 (D) at the tibio-talar joint was determined in a blinded manner with average and SEM graphed (TNF+PAD2+/+ n=11, TNF+PAD2−/− n=10, *p<0.05).