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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Nov 8;9(4):10.1002/wnan.1444. doi: 10.1002/wnan.1444

Figure 2. CeONP Preserves TH+ Neurons in the Substantia Nigra of MPTP-Challenged Mice.

Figure 2

Mice (C57Bl/6) were pretreated with the indicated dose of 10 nm CeONP in saline-citrate, followed by MPTP challenge 5 days later (6 animals per group). Animals were euthanized 7 days after MPTP administration, brains were perfusion fixed, and stained for tyrosine hydroxylase (TH+, brown), a marker of dopaminergic neurons. Nuclei are counterstained with Nissl (blue). Note the almost complete destruction of dopaminergic neurons by MPTP (upper rt panel), which was abrogated in CeONP-treated mice (lower 2 panels).