Table 1.
The mean serum level of bone resorption and formation markers among the five groups
| Group | ACP (µg/L) |
ALK-P (µg/L) |
OCN (ng/L) |
Total calcium (mg/L) |
Inorganic phosphate (mg/L) |
|---|---|---|---|---|---|
| Group I, SHAM rats | 23.20±1.76a | 121.63±3.56b | 3.30±0.25a | 13.30±0.62b | 10.17±0.43c |
| Group II, CMC | 40.47±5.04c | 80.88±5.30a | 3.55±0.31a | 13.03±0.59b | 8.10±1.74b |
| Group III, atorvastatin dissolved in CMC | 29.43±2.00b | 193.83±41.48d | 5.18±0.23c | 13.47±1.06b | 7.27±0.70a |
| Group IV, OVX (model of OP) | 61.95±4.97d | 125.87±3.39c | 6.47±0.15d | 10.43±0.60a | 7.45±0.79a |
| Group V, OVX + atorvastatin | 30.27±0.63b | 120.23±4.66b | 4.93±0.22b | 12.57±0.97b | 10.70±1.26c |
| F-ratio | 120.842 | 30.068 | 58.265 | 17.982 | 12.848 |
| P-value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Notes: There is a significant difference by using one way ANOVA at P<0.05. The same letter means that there is no significant difference between the two groups by using Duncan’s multiple comparison test at P<0.05. The different letters mean that there is a significant difference between the two groups by using Duncan’s multiple comparison test at P<0.05.
Abbreviations: ACP, acid phosphatase; ALK-P, alkaline phosphatase; ANOVA, analysis of variance; OCN, osteocalcin; CMC, carboxy methyl cellulose; OVX, ovariectomized; OP, osteoporosis.