Table 2.
Effects of ebselen and ebsulfur analogs on SIRT functional activities
| Compound ID | SIRT1
|
SIRT2
|
SIRT3
|
SIRT5
|
|---|---|---|---|---|
| IC50 (M) | IC50 (M) | IC50 (M) | IC50 (M) | |
| Ebselen | 1.12E–06 | 4.96E–06 | >1.00E–05 | 6.06E–06 |
| Ebselen oxide | 3.78E–07 | 3.74E–06 | >1.00E–05 | 4.39E–06 |
| Thr101 | 1.23E–07 | 2.75E–06 | >1.00E–05 | 4.07E–06 |
| RBC-2004 | 3.43E–07 | 2.99E–06 | >1.00E–05 | 4.88E–06 |
| RBC-2008 | 1.19E–06 | 7.35E–06 | >1.00E–05 | 7.55E–06 |
| RBC-2010 | 2.83E–07 | 3.70E–06 | >1.00E–05 | 3.22E–06 |
Note: Data shown here represent one of three independent experiments.
Abbreviations: IC50, half maximal inhibitory concentration; SIRT, silent mating-type information regulation 2′.