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. 2017 May 9;7:157. doi: 10.3389/fcimb.2017.00157

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Copyright © 2017 Wang, Yang, Huang, Huang, Zhang, Wang, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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prM-AIDs inhibited ADE of DENV infection in vivo. (A) Schematic representation of the study design. Mice were first administered with naive mouse antibodies (NM-Abs), prM mAb and prM-AIDs, then 24 h later they were challenged with DENV-1 by i.p.. Blood was collected from the vail veins from 0 to 5 days post-infection. (B) Viral copies in the blood cells were quantified by qRT-PCR. (C) Infectious viral particles in the plasma were assessed by plaque assay. (D) Platelets in blood were counted using a hemocytometer under a light microscope. (E,F) The levels of ALT and IL-10 in plasma were measured by ELISA at day 3 post-infection. n = 4–5 mice per group. Error bars show the means ± SEM and pairwise comparisons were performed by non-parametric Mann-Whitney test (^*p < 0.05).