Table S1.
Statistical analysis of HPWD in the MMT model of OA
| Table analyzed | Two-way ANOVA with RM by columns |
|---|---|
| Tw o-way RM ANOVA alpha |
Matching stacked 0.05 |
| Source of Variation | % of total variation | P-value | P-value summary | Significant? |
|---|---|---|---|---|
| Interaction | 0.2692 | 0.995 | ns | No |
| Time | 0.5795 | 0.9713 | ns | No |
| Column factor | 17.59 | 0.0286 | * | Yes |
| Subjects (matching) | 37.74 | <0.0001 | **** | Yes |
| ANOVA table | SS | DF | MS | F (DFn. DFd) | P-value |
|---|---|---|---|---|---|
| Interaction | 2.957 | 5 | 0.5914 | F (5.65)=0.08093 | P=0.9950 |
| Time | 6.367 | 5 | 1.273 | F (5.65)=0.1742 | P=0.9713 |
| r Column facto | 193.2 | 1 | 193.2 | F (1.13)=6.059 | P=0.0286 |
| Subjects (matching) | 414.6 | 13 | 31.89 | F (13.65)=4.364 | P<0.0001 |
| Residual | 475 | 65 | 7.308 |
| Sidak’s multiple comparisons test | Mean diff | 95% CI of diff | Significant? | Summary |
|---|---|---|---|---|
| Sham - MMT | ||||
| (Baseline) day 14 | 2.987 | –2.898 to 8.872 | No | ns |
| (Baseline) day 21 | 4.087 | –1.798 to 9.972 | No | ns |
| (Baseline) day 26 | 4.116 | –1.769 to 10.00 | No | ns |
| (Baseline) day 33 | 4.09 | –1.795 to 9.975 | No | ns |
| (Baseline) day 41 | 3.424 | –2.461 to 9.309 | No | ns |
| (Baseline) day 47 | 3.275 | –2.610 to 9.160 | No | ns |
Notes:
*
P<0.05;
****
P<0.0001.
Abbreviations: MMT, medial meniscal tear; OA, osteoarthritis; ANOVA, one-way analysis of variance, SEM, standard error of the mean; SD, Sprague Dawley; ns, not significant; RM, repeated measures; SS, sum of squares; DF, degrees of freedom; MS, mean square; F, variance of the group means; DFn, degrees of freedom numerator; DFd, degrees of freedom denominator.