Figure 3.

Genetic activation of intestinal Lxrα protects against high-cholesterol diet-induced hypercholesterolemia. (A–C), WT, nr1h3^−/−, and Tg(fabp2a: EGFP- nr1h3) transgenic animals were fed control diets and HCD from 3 to 10 months post-fertilization. The nr1h3^−/− animals showed a statistically significant increase in plasma total cholesterol on the high cholesterol diet, while Tg(fabp2a:EGFP-nr1h3) transgenic animals had lower (but still increased compared to control-diet fed animals) total cholesterol than WT animals. Equal numbers of males and females were used in each cohort. The median values are shown with a horizontal line. Values not sharing a common superscript letter are significantly different at P < 0.05 in 1-way ANOVA.