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. 2017 May 4;12:3509–3520. doi: 10.2147/IJN.S128802

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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AuNPs inhibited the expression of MMP-2, c-Myc and reversed V/E.

Notes: (A) Western blot analyses for MMP-2 and c-Myc in B16F10 cells. (B) AuNPs decreased expression of MMP-2 in B16F10 cells. (C) AuNPs decreased expression of c-Myc in B16F10 cells. (D) Western blot analyses for MMP-2 and ZO-1 in HUVECs. (E) AuNPs decreased expression of MMP-2 in HUVECs. (F) AuNPs increased expression of ZO-1 in HUVECs. (G) Western blot analyses for V/E in B16F10 cells. (H) AuNPs reversed V/E in B16F10 cells. *P<0.05, **P<0.01, and ***P<0.001.

Abbreviations: AuNPs, gold nanoparticles; MMP-2, matrix metalloproteinase-2; ZO-1, zonula occludens-1; HUVECs, human umbilical vein endothelial cells; V/E, vimentin/E-cadherin; Ctrl, control; ns, no significance.