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. 2017 May 4;10:2427–2447. doi: 10.2147/OTT.S133563

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© 2017 Haq et al. This work is published and licensed by Dove Medical Press Limited

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Cyclo-RGDfK(TPP) method of MCTS formation using (A) DU145 cells, (B) DU145GemR cells, (C) PC3 cells, and (D) PC3GemR cells. A total of 10,000 cells were plated per well in a 96-well plate. Cyclo-RGDfK(TPP) peptide was added in a range of concentrations from 12.5 to 100 μM. The control group was the monolayer cells with no cyclo-RGDfK(TPP) peptide added. The images were taken with a digital camera mounted on a phase-contrast inverse light microscope at 10× objective on day 6.

Abbreviations: MCTS, multicellular tumor spheroid; cyclo-RGDfK(TPP), cyclic Arg-Gly-Asp-D-Phe-Lys peptide modified with 4-carboxybutyl-triphenylphosphonium bromide.