FIGURE 4.

Pathological changes of the liver tissues of the mice treated with high-fat diets and mitochondria. (A) Liver tissues were stained with Oil Red O. The excessive accumulation of lipid droplets in mouse liver appeared after the mice were fed with high-fat diet. Mice in mitotherapy group 1 were intravenously injected mitochondria three times in 9 days (once in 3 days), while mice in mitotherapy group 2 received mitochondria six times in 18 days. Representative photomicrographs (200×). (B) Ultrathin sections for mitochondrial observation under TEM. The red arrows pointed to normal mitochondria, while the blue ones pointed to the swelling mitochondria, and the yellow ones pointed to the restored mitochondria.