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. 2017 May 9;10:139. doi: 10.3389/fnmol.2017.00139

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Copyright © 2017 Wang, Zhang, Chen, Liu, Teng, Zhao and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASCT2 downregulation in the hippocampus alleviated depression-like behavior in CSDS mice. (A) mRNA expression of Asct2 after being infected by lentiviruses carrying Asct2-specific (Lenti-535, Lenti-1127, and Lenti-1234) (shASCT2) or scrambled (shSCR) GFP-labeled shRNA, in HT22 hippocampal cells (n = 3, ^**p < 0.01, shASCT2 vs. shSCR; unpaired t-test). (B) Infected region of shASCT2-1127 in the hippocampus. (C,D) Effects of shASCT2 on depression-like behavior in Control (Con) and CSDS mice: the social interaction (C) and forced swim test (D) (n = 7–10; ^*p < 0.05, ^**p < 0.01; two-way ANOVA).