Table 3.
Categorical analysis
| Outcome measure | Normality criterion | Sites | N | BL, n (%) | FU1, n (%) | FU2, n (%) | FU3, n (%) |
|---|---|---|---|---|---|---|---|
| TBUT (s) | >10 | 1 | 38 | 1 (2.6) | 11 (29) | 15 (39) | 20 (53) |
| 2 | 42 | 15 (36) | 39 (93) | 40 (95) | 42 (100) | ||
| SPEED | <10 | 1+2 | 80 | 18 (22) | 65 (81) | 61 (76) | 67 (84) |
| MGS | ≤10 | 1+2 | 80 | 7 (8.8) | 24 (30) | 31 (39) | 28 (35) |
| CFS | <10 | 1 | 38 | 24 (63) | 38 (100) | 34 (89) | 36 (95) |
| 2 | 42 | 42 (100) | 40 (95) | 42 (100) | 42 (100) | ||
| TFO (mOsm/L) | <310 | 1+2 | 20 | 0 (0) | 17 (85) | 17 (85) | 17 (85) |
| ΔTFO (mOsm/L) | <8 | 1+2 | 24 | 0 (0) | 13 (54) | 14 (58) | 16 (67) |
| LLT (nm) | <60 | 1 | 38 | 29 (76) | 31 (82) | 31 (76) | 28 (74) |
Notes: In this analysis, outcome measures were dichotomized to “normal” or “consistent with DED”, according to the criteria listed under the column “Normality criterion”. n, number of eyes with normal values.
Abbreviations: BL, baseline; CFS, corneal fluorescein staining; DED, dry eye disease; FU, follow-up; LLT, lipid layer thickness; MGS, meibomian gland score; SPEED, Standard Patient Evaluation of Eye Dryness; TBUT, tear breakup time; TFO, tear film osmolarity.