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Proposed signaling pathways involved in TP-induced hepatotoxicity. TP suppressed the FXR/SHP pathway via inhibiting the Sirt1 activity, which led to dysregulation of the expression of FXR-targeted genes involved in bile acid homeostasis and gluconeogenesis. Both Sirt1 agonist, SRT1720, and FXR agonist, OCA, reduced TP-induced disruption of hepatic metabolism and liver injury.
