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Stromal cells can be reprogrammed to inducible pluripotent stem (iPS) cells through the transfection of Yamanaka factors (Oct4, Sox2, Klf4 and c-Myc), or through three miRNAs (miR-200c, miR-302, miR-369). Cancer cells can also be reprogrammed to pluripotent cells, so called inducible pluripotent cancer (iPCs) cells, which have reduced tumour initiating capabilities and increased chemosensitivity.
