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Cis-UCA reduces costimulatory molecule expression in unstimulated MDCCs. MDCCs were cultured for 7 days in the presence of cis-UCA (c-UCA) or trans-UCA (t-UCA). Culture with 100 μg/mL cis-UCA caused a significant reduction in CD86 (A), PD-L1 (B), HLA-DR (C), and CD40 (D) MFI. Statistical analysis was done with repeated-measures ANOVA (Friedman test with Dunn multiple comparison posttest). **P < .01, ***P < .001, and ****P < .0001. Lines show medians and interquartile ranges.
