Fig. 5.

LRRC26 KO mimics effect of SLO1 KO in reducing K⁺ efflux in salivary gland secretions. (A) Potassium content was measured from pilocarpine-induced fluid secretion from in vivo parotid glands, for wt (gray) and LRRC26 KO animals. Height of bars shows mean with error bars indicating SEM, whereas circles show individual determinations. Each determination is the average of secretion measured separately from both glands in a single animal, except in one case where only a single gland was obtained. (B) Two bars on the left compare potassium content in submandibular gland saliva from an in vivo measurement, and the two bars on the right show ex vivo potassium content of submandibular salivary secretion. For all comparisons between wt and Lrrc26^−/− glands in both A and B, P < 0.001 for the t test.