Table 3. Dynamic CT perfusion imaging in human studies.
| Author, year | N. | CT technology | Reference standard | Analysis | SE (%) | SP (%) | PPV (%) | NPV (%) | Dose (mSv) |
|---|---|---|---|---|---|---|---|---|---|
| Ho et al., 2010 (57) | 35 | Second DSCT | SPECT (segment) | Quantitative MBF | 83 | 78 | 79 | 82 | 9.1 |
| Bamberg et al., 2011 (58) | 33 | Second DSCT | FFR§ (vessel) | Quantitative MBF | 93 | 87 | 75 | 97 | 10 |
| Wang et al., 2012 (59) | 30 | Second DSCT | QCA + SPECT (vessel) | Visual quantitative MBF and MBV | 100 | 76 | 54 | 100 | 9.5 |
| Huber et al., 2013 (60) | 32 | 256-detector CT | FFR (vessel) | Quantitative MBF | 76 | 100 | 100 | 91 | 9.5 |
| Greif et al., 2013 (61) | 65 | Second DSCT | FFR (vessel) | Quantitative MBF | 95 | 74 | 49 | 98 | 9.7 |
| Rossi et al., 2014 (62) | 80 | Second DSCT | FFR (vessel) | Quantitative MBF | 88 | 90 | 77 | 95 | 9.4 |
| Bamberg et al., 2014 (63) | 31 | Second DSCT | MRI 3T (vessel) | Quantitative MBF and MBV | 100 | 75 | 92 | 100 | 11.08 |
All the studies but one (57) used adenosine at a dose of 0.14 mg/kg/min. Ho et al. used dipyridamole at a dose of 0.56 mg/Kg (57). CT, computed tomography; DSCT, dual-source CT scanner; FFR, fractional flow reserve; N., number of patients; mSv, millisievert; MRI, magnetic resonance imaging; MBF, myocardial blood flow; MBV, myocardial blood volume; NPV, negative predictive value; PPV, positive predictive value; QCA, quantitative coronary angiography; SE, sensitivity; Semiq, semiquantitative analysis; SP, specificity; SPECT, myocardial perfusion scan. §, accuracy of CT perfusion integrated with the coronary anatomic data.