Table 4. Dynamic CT perfusion imaging in animal studies.
| Author | N. | CT technology | Reference standard | Analysis | Dose (mSv) |
|---|---|---|---|---|---|
| Bamberg et al., 2012 (70) | 7 pigs | DS 2° g | Microsphere MBF | Quantitative MBF | 10.6 |
| Schwarz et al., 2013 (71) | 6 pigs | DS 2° g | Microsphere MBF | Quantitative MBF + attenuation values (HU) | 11.3+0.88 |
| Rossi et al., 2013 (72) | 7 pigs | DS 2° g | CBF and FFR | Quantitative MBF | 17.1 |
| Bamberg et al., 2014 (73) | 12 pigs | DS 2° g | Histopathology microsphere MBF | Quantitative MBF, MBV, Ktrans | NA |
All the studies but one (72) used adenosine at a dose of 0.14 mg/kg/min. Rossi et al. used adenosine at a dose of 0.50 mg/kg/min (72). CBF, coronary blood flow; CT, computed tomography; DSCT, dual-source CT scanner; FFR, fractional flow reserve; HU, Hounsfield unit; Ktrans, permeability constant; mSv, millisievert; MBF, myocardial blood flow; MBV, myocardial blood volume; N., animals’ number; NA, non assessable.