Table 1.

Significant increase in the protein levels of various inflammatory mediators in the hippocampus of TMEV-infected mice during acute seizure activity period. Statistics: Two-way ANOVA, Bonferroni posttest, ^#p<0.05, ^*p<0.01, ^†p<0.001; SEM, standard error of the mean. (TNFα, tumor necrosis factor-α; IFNγ, interferon-γ; IL, interleukin; CXCL1, C-X-C motif chemokine ligand 1)

	Fold change (relative to PBS-injected control mice)
	1 dpi (n = 8)		5 dpi (n = 6)		14 dpi (n = 5)
Cytokine	Average	SEM	Average	SEM	Average	SEM
TNFα	6.9	0.6	206.2†	14.9	34.8#	7.1
IFNγ	4.5	0.8	21,734.4†	3123.2	99.1	21.6
IL-1β	6.9	1.1	58.2†	5.4	46.6	13.5
IL-10	2.3	0.3	47.2†	6.0	9.6	1.9
IL-12p70	2.5	0.3	3.0#	0.5	6.0†	1.0
IL-4	1.0	0.2	0.8	0.1	1.3	0.3
IL-2	2.4	0.3	14.4†	4.2	4.9	0.7
IL-5	2.0	0.1	10.8*	2.5	2.6	1.2
CXCL1	4.6	0.3	30.0†	4.3	2.4	0.3

Statistics: two-way ANOVA, Bonferroni posttest, ^†p<0.001; ^#p<0.05; ^*p<0.01. CXCL1, C-X-C motif chemokine ligand 1.