Fig. 3.

Delta rhythmicity is increased in children with Angelman syndrome relative to neurotypical controls during wakefulness. Black: neurotypical, red: AS. a Schematic showing EEG electrode placement according to the 10-20 recording system. Delta power and dynamics are calculated for each electrode and results averaged by region. Representative EEGs from b a neurotypical child and c a child with AS illustrate enhanced delta power, generalized across recording sites. d, e Power spectra of group data from occipital electrodes (NT: n = 54, AS: n = 26; shading indicates ±sem) illustrate an increase in delta power in AS; other regional spectra are shown in Additional file 3: Figure S3. f Group analyses reveal increased delta power generalizes across the neocortex (***p < 0.0001, Student’s t test). g Delta dynamics (IQR) are also increased in all regions (***p < 0.0001)