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. 2017 May 8;18:212. doi: 10.1186/s13063-017-1949-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Participant time line. Time schedule of enrolment, intervention, assessments and visits for participants. CRF Case report form, HbA1c Glycated haemoglobin, IGF-1 Insulin-like growth factor 1, IGFBP-3 Insulin-like growth factor-binding protein 3