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. 2017 May 8;10:24. doi: 10.1186/s13072-017-0129-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Model of epigenome editing in primary T cells. a dCas9-TET1CD demethylates the Foxp3 CNS2 locus and enhances Foxp3 expression weakly. b dCas9-p300CD acetylates the Foxp3 promoter locus, activates transcription in coordination with the TGF-β signal, and promotes immunosuppressive function