Fig. 5.

KB-R7943 (62.5 pmol) effects on epileptiform EEG activity induced by 4-AP (3 nmol) in control (colourless bars) and MSG-treated (black bars) rats. The latency, duration and net amplitude of the first burst recorded in the right hippocampus after i.c.v. infusion of the drugs alone or in combination are presented in panel a, b and c, respectively. Furthermore, the duration of ictal activity d and elapsed time before EEG activity normalization e were also measured in the same conditions described before. Activity recorded in the right hippocampus was considered for these measurements because it was the region closest to the infusion location. Data represent the mean ± SEM from four animals for each infusion scheme (subgroups: 4-AP, KB-R7943, and 4-AP + KB-R7943) in each group (CTL and MSG). Statistically different at *p < 0.05 for all subgroups compared to that in control rats with 4-AP; @p < 0.05 for all subgroups compared to that in MSG-treated rats with 4-AP; &p < 0.05 for all subgroups compared to that in control rats with KB-R7943; #p < 0.05 for all subgroups compared to that in control rats with 4-AP + KB-R7943; and §p < 0.05 between KB-R7943 alone and 4-AP + KB-R7943 in MSG-treated animals; tested using two-way ANOVA with post hoc Tukey’s test. Furthermore, p and F values, including degree of freedom, for each variable compared by two-way ANOVA are summarized in Additional File 2