Table 2.
Features and epileptiform behaviours observed in the studied groups
| Group | Weight (g) | Subgroups | Bursts | Behaviours | Death |
|---|---|---|---|---|---|
| CTL | 254.99 ± 20.03 | 4-AP | 1–3 | facial, head and forelimb clonus, wild running and rearing | Not observed |
| KB-R7943 | 0-2b,c | clonic convulsions of head | Not observed | ||
| 4-AP + KB-R | 0-4b,c | clonic convulsions of head | Not observed | ||
| GMS | 164.53 ± 10.70a | 4-AP | 6-11b | facial, head and forelimb clonus and GTCS | Observed in 1 animal |
| KB-R7943 | 0-1b,c | facial clonus | Not observed | ||
| 4-AP + KB-R | 0-1b,c | facial clonus | Not observed |
a p < 0.01 CTL vs. MSG animals, using Student’s t-test; b p < 0.05 all subgroups compared to CTL/4-AP, and c p < 0.05 all subgroups compared to MSG/4-AP, both using Mann–Whitney U test. Doses: 3 nmol of 4-AP and 62.5 nmol of KB-R7943 (also named KB-R)