Figure 1.

Molecular mechanisms involved in macrophage inflammatory protein-2 secretion of macrophages. The Figure illustrates several reciprocal molecular pathways for the secretion of MIP-2. These include: LPS-mediated induction of MIP-2, IL-6, IL-1β, TNF-α through the NF-κB/MAPK signaling pathway; IL-6-mediated induction of MIP-2 through the NF-κB/MAPK signaling pathway; TNF-α-mediated induction of MIP-2 through the NF-κB/MAPK, caspase-3 signaling pathway; FasL-mediated induction of MIP-2 through the caspase-3 signaling pathway; Ca²⁺- and ATP-mediated induction of MIP-2 through the PI3K signaling pathway; IL-1β-mediated induction of MIP-2 through the NF-κB/MAPK signaling pathway; IFN-γ and IL-10-mediated inhibition of MIP-2, IL-6, IL-1β and TNF-α through the JAK/STAT3 signaling pathway; SOCS3-mediated inhibition of JAK/STAT3. MIP-2: Macrophage inflammatory protein-2; TNF-α: Tumor necrosis factor-α; IFN-γ: Interferon-γ; IL: Interleukin; LPS: Lipopolysaccharide.