Table 4.
Univariate and multivariate analyses of factors affecting overall survival
| Variables |
Univariate analysis for OS |
Multivariate analysis for OS |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| NLR > 2.9 | 1.969 | 1.190-3.259 | 0.008 | 1.866 | 1.048-3.322 | 0.034 |
| Age ≤ 50 yr | 1.532 | 0.913-2.569 | 0.106 | |||
| Female | 2.035 | 0.625-6.623 | 0.238 | |||
| HBsAg (+) | 1.055 | 0.327-3.402 | 0.929 | |||
| HBV-DNA > 1 × 103 | 1.258 | 0.709-2.234 | 0.432 | |||
| AFP ≥ 400 ng/mL | 2.026 | 1.163-3.527 | 0.013 | 1.863 | 1.024-3.392 | 0.042 |
| ALT ≤ 40 U/L | 1.122 | 0.684-1.839 | 0.649 | |||
| Hgb > 130 g/L | 1.964 | 0.987-3.909 | 0.054 | |||
| PLT > 100 × 109/L | 1.168 | 0.467-2.916 | 0.740 | |||
| Child A | 1.090 | 0.564-2.106 | 0.798 | |||
| ICGR15 ≤ 10% | 1.642 | 0.746-3.610 | 0.218 | |||
| Multiple tumors | 1.676 | 1.022-2.748 | 0.041 | 1.084 | 0.627-1.876 | 0.772 |
| Maximum diameter of tumor > 5 cm | 1.869 | 0.973-3.593 | 0.061 | |||
| Bilobular disease | 2.764 | 1.153-6.628 | 0.023 | 3.292 | 1.215-8.918 | 0.019 |
| Adjacent organ invaded | 1.268 | 0.756-2.127 | 0.369 | |||
| Major hepatectomy | 1.145 | 0.597-2.195 | 0.683 | |||
| Pringle maneuver | 1.937 | 0.950-3.952 | 0.069 | |||
| Operation time > 180 min | 1.352 | 0.819-2.233 | 0.238 | |||
| Intraoperative blood loss > 1000 mL | 1.721 | 0.957-3.096 | 0.070 | |||
| Intraoperative blood transfusion | 1.485 | 0.901-2.448 | 0.121 | |||
| Surgical margin ≤ 1 cm | 1.868 | 1.024-3.408 | 0.042 | 1.195 | 0.596-2.394 | 0.616 |
| Histologic grade III-IV | 1.220 | 0.736-2.020 | 0.440 | |||
| Postoperative complication | 1.467 | 0.807-2.667 | 0.209 | |||
| Postoperative hospital stay ≤ 10 d | 1.078 | 0.646-1.798 | 0.774 | |||
NLR: Neutrophil-to-lymphocyte ratio; OS: Overall survival; HBV: Hepatitis B virus; AFP: Alpha fetoprotein; ALT: Alanine aminotransferase; PLT: Platelet.