Table 5.
Univariate and multivariate analyses of factors affecting disease-free survival
| Variables |
Univariate analysis for DFS |
Multivariate analysis for DFS |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| NLR > 2.9 | 1.720 | 1.017-2.907 | 0.043 | 1.553 | 0.850-2.837 | 0.153 |
| Age ≤ 50 yr | 1.424 | 0.842-2.409 | 0.188 | |||
| Female | 1.593 | 0.384-6.610 | 0.522 | |||
| HBsAg (+) | 1.314 | 0.407-4.249 | 0.648 | |||
| HBV-DNA > 1 × 103 | 1.426 | 0.772-2.634 | 0.257 | |||
| AFP ≥ 400 ng/mL | 2.099 | 1.196-3.684 | 0.010 | 1.732 | 0.954-3.146 | 0.071 |
| ALT ≤ 40 U/L | 1.272 | 0.771-2.098 | 0.346 | |||
| Hgb > 130 g/L | 2.629 | 1.266-5.460 | 0.010 | 2.051 | 0.940-4.476 | 0.071 |
| PLT ≤ 100 × 109/L | 1.147 | 0.413-3.186 | 0.793 | |||
| Child B | 1.254 | 0.631-2.492 | 0.518 | |||
| ICGR15 ≤ 10% | 2.470 | 1.052-5.796 | 0.038 | 2.134 | 0.870-5.236 | 0.098 |
| Multiple tumors | 1.189 | 0.709-1.992 | 0.512 | |||
| Maximum diameter of tumor > 5 cm | 1.865 | 0.944-3.686 | 0.073 | |||
| Bilobular disease | 1.778 | 0.753-4.199 | 0.189 | |||
| Adjacent organ not invaded | 1.119 | 0.659-1.899 | 0.677 | |||
| Major hepatectomy | 1.253 | 0.635-2.474 | 0.516 | |||
| Pringle maneuver | 1.922 | 0.933-3.960 | 0.076 | |||
| Operation time ≤ 180 min | 1.067 | 0.638-1.785 | 0.805 | |||
| Intraoperative blood loss > 1000 mL | 1.854 | 1.012-3.396 | 0.046 | 1.258 | 0.649-2.437 | 0.497 |
| Intraoperative blood transfusion | 1.655 | 0.972-2.817 | 0.064 | |||
| Surgical margin ≤ 1 cm | 1.492 | 0.827-2.690 | 0.183 | |||
| Histologic grade I-II | 1.083 | 0.648-1.808 | 0.761 | |||
| Postoperative complication | 1.173 | 0.608-2.264 | 0.634 | |||
| Postoperative hospital stay > 10 d | 1.041 | 0.616-1.759 | 0.882 | |||
NLR: Neutrophil-to-lymphocyte ratio; DFS: Disease-free survival; HBV: Hepatitis B virus; AFP: Alpha fetoprotein; ALT: Alanine aminotransferase; PLT: Platelet.