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. 2017 May 7;23(17):3133–3141. doi: 10.3748/wjg.v23.i17.3133

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Schematic diagram of staging of hepatic fibrosis. S1: Portal fibrosis characterized by mild fibrous expansion of portal tracts; S2: Periportal fibrosis showing fine strands of connective tissue in zone 1 with only rare portal-portal septa; S3: Septal fibrosis manifested by connective tissue bridges that link portal tracts with other portal tracts and central veins; minimally distorted architecture, but no regenerative nodules; S4: Cirrhosis showing bridging fibrosis and nodular regeneration.