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. 2015 Oct 5;14(5):423–431. doi: 10.1038/cmi.2015.89

Figure 4.

Figure 4

TGF-β mediates the up-regulation on Treg cells in lupus patients. In the co-culture of lupus patients PBMC and UC MSCs (10:1), an anti-TGF-β antibody and an anti-IL6 antibody, alone or in combination, was added; 72 h later, the percentages of CD4+CD25+Foxp3+ Treg (a), CD4+IL17A+ Th17 (c), and the MFI of Foxp3 (b) were analyzed by flow cytometry. TGF-β siRNA-UC MSCs were used to down-regulate TGF-β expression on UC MSCs (d), and the percentages of CD4+CD25+Foxp3+ Treg (e) and CD4+IL17A+ Th17 (f) were assessed by flow cytometry. *P < 0.05, **P < 0.01.