Figure 3.

Regnase-1 may be a master stress responsive gene that, when dysregulated, can lead to disease. Regnase-1 has been demonstrated to be a rapid response gene. We propose that Regnase-1 may function as a master regulator that facilitates cell adaptation to microenvironmental changes. After encountering microenvironmental changes, cells respond appropriately either by upregulating Regnase-1 to ‘start the engine' or by downregulating Regnase-1 to ‘release the brake' (a). To ensure the proper function of Regnase-1, cells tightly regulate the precise Regnase-1 levels at each step. Both gain and loss of Regnase-1 function result in various diseases, including immune related diseases and other yet to be identified diseases (b).