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SK channel activation and overexpression of mitochondrial SK2 channels decreases glutamate-induced accumulation of mitochondrial calcium. Representative measurements of mitochondrial calcium levels following glutamate exposure (16 h) in the presence or absence of CyPPA (CY), in (a) wildtype HT22 cells or HT22 cells overexpressing (b) GFP versus SK2, (c) mitoGFP versus mitoSK2, and (d) SK2 versus mitoSK2. Data are presented as mean ± SD, n=3, *P<0.05, **P>0.01, ***P<0.001
