Figure 6.

SK2 channel activation reduces ATP-dependent mitochondrial calcium uptake in HT22 cells. (a) Mitochondrial calcium uptake kinetics in HT22[mtAEQ] cells stimulated with ATP. (b–f) ATP-induced changes in mitochondrial calcium uptake in cells pre-treated with (b) KB-R7943 (KBR) and antimycin A (AA), (c) CyPPA (CY), (d) apamin (AP), (e) quinine (QUI) and (f) glibenclamide (GLI). In (d–f), CyPPA co-treatment was included. Data are calculated as peak amplitude (% of control) and presented as mean±SEM, n=6–8. *P<0.05, **P<0.01, ***P<0.001 compared to control, ns not significant