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. 2016 Feb 4;10(6):806–824. doi: 10.1016/j.molonc.2016.01.008

Figure 1.

Figure 1

Meisoindigo effectively inhibits the growth of gemcitabine‐resistant cells and reduces CSC fractions. (A) Structure of meisoindigo. (B) Anti‐proliferative effect in PDACs. The cells were treated with increasing concentrations of meisoindigo. Cell viability was determined by the number of treated over control cells. The IC50 [μM] values were calculated from dose–response curves. (C) Anti‐proliferative effect in Jopaca‐1 under hypoxia (1% O2). (D) CD133+ population was declined after 24 h treatment with meisoindigo (Mei) (20 μM), while elevated by gemcitabine (Gem). The percentage of CD133+cell was highlighted. (E) Meisoindigo reduced ESA+/CD24+/CD44+ cell population. The percentage of ESA+/CD24+/CD44+ (upper right) and ESA+/CD24−/CD44− (lower left) were highlighted.