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. 2016 Apr 1;10(7):966–980. doi: 10.1016/j.molonc.2016.03.006

Figure 3.

Figure 3

Inhibitory effect of Compounds NP‐G2‐011 and NP‐G2‐044 on filopodial formation. (A) Cells with wild‐type fascin were treated with bradykinin to induce filopodial formation. Addition of Compounds NP‐G2‐011 and NP‐G2‐044 blocked bradykinin‐induced filopodial formation. (B) 4T1 cells expressing fascin(E391A) mutant formed filopodia upon bradykinin treatment. Filopodial formation in these cells was resistant to Compound NP‐G2‐044 inhibition. (C) Quantification of data in A and B. Error bars, mean±SEM. *p < 0.01; **p < 0.005. Scale bar, 10 μm.