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. 2016 Jun 26;10(8):1266–1282. doi: 10.1016/j.molonc.2016.06.003

Figure 2.

Figure 2

SNHG16 expression is regulated by the Wnt signaling pathway. Correlation of c‐Myc and SNHG16 expression in CRC (largeRNAseq cohort) (n = 314). Spearman's ρ = 0.4, p < 0.05 (A). SNHG16 expression in DLD1 cells transfected with 20 or 40 nm Scr or β‐catenin siRNA, quantified by RT‐qPCR. As a positive control of Wnt‐inactivation the well‐known Wnt target c‐Myc was also quantified (B). The expression of dnTCF1 or dnTCF4 was induced by doxycycline (dox) in stably transfected DLD1 cells. The SNHG16 expression was measured at different time points using RT‐qPCR. c‐Myc was included as a positive control (C). Expression analysis of SNHG16 and c‐Myc in HCT116 cells transfected with 50 nM of c‐Myc siRNAs or Scr (RT‐qPCR) (D). Data are presented as ±sd. of three biological replicates, *p < 0.05 (B–D).