Table 3.
Peaks containing a p53 response element, as identified by p53scan (Smeenk et al., 2008), from the ChIP‐Seq experiment in Figure 4 of the manuscript were divided into three groups (WT, K120R or common). Motif analysis using the HOMER motif discovery algorithm was performed to detect enrichment for other transcription factor binding sites (Heinz et al., 2010).
| WT | K120R | Common | ||||||
|---|---|---|---|---|---|---|---|---|
| A | Ba | C | A | Bb | C | A | Bc | C |
| Mef2c | 367 | 1 × 10−77 | NRF | 150 | 1 × 10−57 | Mef2a | 85 | 1 × 10−23 |
| GSC | 482 | 1 × 10−62 | BMAL1 | 498 | 1 × 10−46 | Mef2c | 87 | 1 × 10−23 |
| BMAL1 | 410 | 1 × 10−61 | HIF‐1b | 343 | 1 × 10−44 | Smad4 | 106 | 1 × 10−16 |
| Mef2a | 318 | 1 × 10−57 | CP2 | 61 | 1 × 10−42 | CP2 | 23 | 1 × 10−14 |
| NPAS2 | 308 | 1 × 10−57 | NPAS2 | 294 | 1 × 10−24 | GSC | 104 | 1 × 10−12 |
| TEAD4 | 190 | 1 × 10−39 | Arnt | 198 | 1 × 10−24 | Smad2 | 88 | 1 × 10−10 |
| CRX | 502 | 1 × 10−36 | Mef2a | 90 | 1 × 10−15 | CRX | 123 | 1 × 10−9 |
| Foxa2 | 133 | 1 × 10−30 | Pit1 | 160 | 1 × 10−15 | BMAL1 | 113 | 1 × 10−8 |
| TBX1 | 61 | 1 × 10−22 | Mef2c | 95 | 1 × 10−15 | Smad3 | 130 | 1 × 10−7 |
| CP2 | 46 | 1 × 10−21 | Egr1 | 137 | 1 × 10−14 | NPAS2 | 76 | 1 × 10−6 |
A: Motif Name; B: # of target sequences with motif; C: p‐value.
a
of 1464.
b
of 1406.
c
of 468.