Table 2.
Univariate and multivariate analysis of parameters from the validation group. Using univariate analysis, the microRNA profile, Karnofsky performance score (KPS), MGMT methylation (MGMT) were also associated with survival in the trial cohort. Four different multivariate analyses, using survival and one other variable stated in the table, showed that the microRNA profile and KPS were independently associated with survival (although only KPS was significant after multiple testing correction (p = 0.042)). IDH1 refers to IDH1 mutation status.
| Variable | Number of subjects | HR | 95% CI | p‐value |
|---|---|---|---|---|
| Univariate analysis | ||||
| MGMT | 71 | 0.59 | 0.36–0.96 | 0.034 |
| IDH1 | 70 | 0.55 | 0.23–1.29 | 0.169 |
| KPS | 73 | 1.82 | 1.17–2.82 | 0.007 |
| Age | 73 | 1.01 | 0.99–1.03 | 0.546 |
| Gender | 73 | 0.87 | 0.54–1.41 | 0.579 |
| miR profile | 73 | 0.58 | 0.35–0.95 | 0.031 |
| Variable | HR | 95% CI | p‐value | |
| Multivariate analysis (68 subjects) | ||||
| MGMT | 0.71 | 0.43–1.18 | 0.185 | |
| KPS | 2.02 | 1.31–3.12 | 0.001 | |
| IDH | 0.74 | 0.31–1.77 | 0.493 | |
| miR profile | 0.59 | 0.35–0.99 | 0.046 | |