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. 2016 Aug 18;10(9):1461–1472. doi: 10.1016/j.molonc.2016.07.012

Figure 5.

Figure 5

PARP1 inhibitors specifically target MNA NB cell lines. A) Pathway analysis of module 6 genes highlights enrichment in double stranded DNA repair pathways (R: Reactome, K: KEGG, N: NCI Pathways). B) Western blotting reveals high and low MNA NB cell lines. C) Dose response experiments reveal that the PARP1 inhibitor BYK204165 more potently suppresses the growth of MNA vs. NA NB cell lines. D&E) BYK204165 selectively induces the expression of the apoptotic markers cleaved‐PARP and cleaved‐Caspase3 (CASP3) in MNA NB cell lines.