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. 2016 Aug 25;10(9):1485–1496. doi: 10.1016/j.molonc.2016.08.004

Figure 4.

Figure 4

Nanoparticle encapsulated citral reduces ALDH1A3‐mediated MDA‐MB‐231 tumor growth. A) Nanoparticle encapsulated citral (citral‐NP) quantification via HPLC illustrated the two isomers present in citral and estimated the citral concentration. Three peaks present on the HPLC chromatogram represent the “non‐citral” products in the SIGMA citral (elute 3.2 min), the neral or E isomer (elute 6.4 min), and the geranial or Z isomer (elute 6.9 min). B) The effect of 100 μM citral‐NP and unencapsulated citral in the Aldefluor assay performed on MDA‐MB‐468 cells and MDA‐MB‐231 ALDH1A3‐OE cells. C) Tumor measurements in mice injected with MDA‐MB‐231 vector control or ALDH1A3‐OE cells, with or without citral‐NP treatment. D) The resulting tumor weights. B, C, D) Significance determined by one‐way ANOVA with Tukey's post‐hoc test.