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. 2016 Aug 25;10(9):1485–1496. doi: 10.1016/j.molonc.2016.08.004

Figure 6.

Figure 6

Citral reduces ALDH1A3‐mediated expression of retinoic acid‐inducible genes. Relative mRNA expression levels of retinoic acid‐inducible genes RARβ, RARRES1, and ELF3, pluripotency genes SOX2, NANOG, and POU5F1/Oct4, and CSC‐associated genes ITAG6, ALDH1A1, and CD44 was quantified by QPCR, normalized to control and B2M levels in MDA‐MB‐231 ALDH1A3‐OE cells (A) and MDA‐MB‐468 cells (B) with increasing citral treatment for 24 h compared to vehicle no treatment control. Significance of ALDH1A3‐OE compared to control MDA‐MB‐231 cells (A) and ALDH1A3 knockdown compared to control MDA‐MB‐468 cells (B) was determined by t‐test. A, B) Significance of citral treatments compared to vehicle no treatment determined by one‐way ANOVA with Dunnett's post‐hoc test.