Table 3.

Hydrodynamic diameter (Z_ave), PDI and encapsulation efficiency of SPION and Gemcitabine in (PLGA-Gem-SPION) ± PEG nanoparticles. The Gemcitabine ratio and PEG were considered as dependent variables. Z_ave and PDI were obtained by zetasizer

PDI* Mean	* ${\mathbf{Size}}_{\mathit{ave}}\left(\mathbf{nm}\right)$ Mean±SD	%EE (Gem) Mean±SD	%EE(SPION)Ŧ Mean±SD	SPION )mg/mL)	$\frac{m_{\mathbf{Gem}}}{m_{\mathbf{Polymer}}}$	PLGA	PEG	Sucrose (%)
0.08	8.0±174.0	16.1±2.0	47.7±2.6	10	0.04	20	5	1
0.17	178.5±9.6	17.1±0.4	0.6±40.1	10	0.08	20	0	1
0.08	10.0±180.0	16.0±1.0	48.2±2.1	10	0.04	25	5	1
0.09	173.4±0.5	13.8±0.3	3.4±44.9	10	0.08	25	0	1

^*Obtained by UV-Vis Spectrophotometer.

^Ŧ Obtained by atomic absorption spectrophotometer