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Loading content and encapsulation efficiency of Gem and (or) SPION in formulations. Encapsulation efficiency of SPION and Gemcitabine were determined in triplicate using atomic absorption spectrophotometer and UV-Vis spectrophotometer, respectively
| Formulation |
Encapsulation efficiency (%)
|
Loading content
(%) |
||
|---|---|---|---|---|
| Gem( UV-Vis) | SPION(AAS) | Gem | SPION | |
| SPION-PLGA | - | 50.1±1.1 | - | 28.6 |
| PLGA-Gem | 13.2±1.3 | - | 3. 8 | - |
| SPION-PLGA-Gem | 16.1±2.2 | 48.2±2.1 | 2.8 | 27.8 |
