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Enhancement ratios and survival (%) of MCF-7 cells in various treatment groups after 48 h incubation. The concentration of formulations is equivalent to IC50 of Gemcitabine (10.3 µM
| Formulation | Survival (%) | Enhancement ratio | P -value * |
|---|---|---|---|
| PLGA-SPION | 93.1±1.2 | - | - |
| Gem | 50.0±0.0 | 1.00 | - |
| PLGA-Gem | 32.7±1.1 | 1.53 | 0.015 |
| SPION-PLGA-Gem | 26.2±2.3 | 1.89 | 0.006 |
P-values are calculated compared to Gemcitabine group
