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. 2017 May 9;8:837. doi: 10.3389/fmicb.2017.00837

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Copyright © 2017 Cheng, Liang, Zhang, Hu, Gong, Cai, Zhang, Zhang, Ge, Ji, Guo, Feng, Sun, Yang, Lei, Han and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of E. faecalis challenge and phage therapy on the composition of the gut microbiota. The composition of the gut microbiota in the feces of challenged and normal mice that were treated with or without phage EF-P29 was analyzed using 16S rRNA gene sequencing (n = 6 for each group). (A) A plot was generated using the weighted version of the UniFrac-based PCoA. (B) Bacterial taxonomic profiling at the phylum level of intestinal bacteria identified in different mouse groups. (C) Heatmapping shows that the abundance of intestinal bacteria at the genus level was significantly altered by treatment with phage EF-P29 in challenged and normal mice. (D) The cladogram demonstrates the phylogenetic distribution of microbial lineages in fecal samples obtained from differently treated mice.